Drug General Information
Drug ID
D0IT5D
Former ID
DIB018826
Drug Name
alpha-propyldopacetamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [468156]
Structure
Download
2D MOL
Formula
C11H15NO3
InChI
InChI=1S/C11H15NO3/c1-2-3-8(11(12)15)7-4-5-9(13)10(14)6-7/h4-6,8,13-14H,2-3H2,1H3,(H2,12,15)
InChIKey
GDXQWRJYXZXWMT-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Tyrosine 3-monooxygenase Target Info Inhibitor [543389]
Tryptophan 5-hydroxylase-1 Target Info Inhibitor [543387]
L-Tryptophan hydroxylase 2 Target Info Inhibitor [543388]
BioCyc Pathway Catecholamine biosynthesisPWY66-401:Superpathway of tryptophan utilization
Serotonin and melatonin biosynthesis
KEGG Pathway Tyrosine metabolism
Metabolic pathways
Dopaminergic synapse
Prolactin signaling pathway
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Alcoholismhsa00380:Tryptophan metabolism
Serotonergic synapse
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
Parkinson disease
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathwayP04371:5-Hydroxytryptamine biosynthesis
Pathway Interaction Database ATF-2 transcription factor network
AP-1 transcription factor network
p38 signaling mediated by MAPKAP kinases
Alpha-synuclein signaling
PathWhiz Pathway Catecholamine BiosynthesisPW000163:Tryptophan Metabolism
WikiPathways Monoamine Transport
SIDS Susceptibility Pathways
Biogenic Amine Synthesis
Dopaminergic Neurogenesis
Metabolism of amino acids and derivatives
Dopamine metabolism
Parkinsons Disease Pathway
Nicotine Activity on Dopaminergic NeuronsWP706:SIDS Susceptibility Pathways
Tryptophan metabolism
References
Ref 468156(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5095).
Ref 543387(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1241).
Ref 543388(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1242).
Ref 543389(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1243).

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