Drug Information

Drug General Information
Drug ID
D0C6AP
Former ID
DNC005054
Drug Name
2-(4-Hydroxy-phenyl)-7-methyl-benzofuran-5-ol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527198]
Structure
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2D MOL

3D MOL
Formula
C15H12O3
Canonical SMILES
CC1=C2C(=CC(=C1)O)C=C(O2)C3=CC=C(C=C3)O
InChI
1S/C15H12O3/c1-9-6-13(17)7-11-8-14(18-15(9)11)10-2-4-12(16)5-3-10/h2-8,16-17H,1H3
InChIKey
FUWUZPRNKPGRGX-UHFFFAOYSA-N
PubChem Compound ID
10285954
Target and Pathway
Target(s) Estrogen receptor Target Info Inhibitor [527198]
Estrogen receptor beta Target Info Inhibitor [527198]
KEGG Pathway Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Proteoglycans in cancerhsa04915:Estrogen signaling pathway
NetPath Pathway FSH Signaling Pathway
EGFR1 Signaling Pathway
RANKL Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by HDAC Class II
Plasma membrane estrogen receptor signaling
LKB1 signaling events
Regulation of Telomerase
ATF-2 transcription factor network
AP-1 transcription factor network
FOXM1 transcription factor network
Validated nuclear estrogen receptor alpha network
Signaling mediated by p38-alpha and p38-beta
FOXA1 transcription factor networker_nongenomic_pathway:Plasma membrane estrogen receptor signaling
Validated nuclear estrogen receptor beta network
Reactome Nuclear signaling by ERBB4
Nuclear Receptor transcription pathwayR-HSA-383280:Nuclear Receptor transcription pathway
WikiPathways Estrogen signaling pathway
Nuclear Receptors Meta-Pathway
Estrogen Receptor Pathway
Signaling by ERBB4
JAK/STAT
Integrated Pancreatic Cancer Pathway
Leptin signaling pathway
miR-targeted genes in muscle cell - TarBase
Integrated Breast Cancer Pathway
Nuclear ReceptorsWP706:SIDS Susceptibility Pathways
Ovarian Infertility Genes
Nuclear Receptors
References
Ref 527198Bioorg Med Chem Lett. 2004 Oct 4;14(19):4925-9.7-Substituted 2-phenyl-benzofurans as ER beta selective ligands.
Ref 527198Bioorg Med Chem Lett. 2004 Oct 4;14(19):4925-9.7-Substituted 2-phenyl-benzofurans as ER beta selective ligands.

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