Drug Information

Drug General Information
Drug ID
D06GTI
Former ID
DIB018894
Drug Name
AS96
Synonyms
AS 96; AS-96
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467714]
Structure
Download
2D MOL

3D MOL
Formula
C27H30N8O4
InChI
InChI=1S/C27H30N8O4/c1-4-11-34-25-23(26(37)35(12-5-2)27(34)38)28-24(29-25)20-17-21(30-31(20)3)39-18-22(36)33-15-13-32(14-16-33)19-9-7-6-8-10-19/h4-10,17,30H,1-2,11-16,18H2,3H3/b24-20-
InChIKey
ZGPHNPBSZODLNU-GFMRDNFCSA-N
PubChem Compound ID
10174812
PubChem Substance ID
15168882, 30383374, 40264397, 74831569, 135649965, 139629086, 163322959
Target and Pathway
Target(s) Adenosine A2b receptor Target Info Antagonist [527796]
KEGG Pathway Rap1 signaling pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Alcoholism
NetPath Pathway TGF_beta_Receptor Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database C-MYB transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolism
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 467714(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 442).
Ref 527796Pharmacological characterization of novel adenosine ligands in recombinant and native human A2B receptors. Biochem Pharmacol. 2005 Nov 25;70(11):1601-12. Epub 2005 Oct 10.

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