Drug Information

Drug General Information
Drug ID
D01MIP
Former ID
DCL000292
Drug Name
SU5614
Synonyms
SU 5614; SU-5614; (3Z)-5-chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one; 5-Chloro-3-[(3,5-dimethylpyrrol-2-yl)methylene]-2-indolinone
Drug Type
Small molecular drug
Indication Airway inflammation [ICD9: 460-519; ICD10:J00-J99] Terminated [547279]
Company
Sugen Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C15H13ClN2O
Canonical SMILES
CC1=CC(=C(N1)C=C2C3=C(C=CC(=C3)Cl)NC2=O)C
InChI
1S/C15H13ClN2O/c1-8-5-9(2)17-14(8)7-12-11-6-10(16)3-4-13(11)18-15(12)19/h3-7,17H,1-2H3,(H,18,19)/b12-7-
InChIKey
XLBQNZICMYZIQT-GHXNOFRVSA-N
CAS Number
CAS 186611-56-3
PubChem Compound ID
6536806
PubChem Substance ID
11643921, 14848458, 26759569, 43183004, 50086910, 53789945, 57370873, 77345463, 114611045, 121379919, 134338948, 134340445, 135278881, 139404012, 160706949, 162248874, 163364456, 163687286, 164765089, 243196500, 252162896
Target and Pathway
Target(s) FL cytokine receptor Target Info Inhibitor [537173]
KEGG Pathway Cytokine-cytokine receptor interaction
Hematopoietic cell lineage
Pathways in cancer
Transcriptional misregulation in cancer
Acute myeloid leukemia
Central carbon metabolism in cancer
References
Ref 547279Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014776)
Ref 537173FMS-like tyrosine kinase 3-internal tandem duplication tyrosine kinase inhibitors display a nonoverlapping profile of resistance mutations in vitro. Cancer Res. 2009 Apr 1;69(7):3032-41. Epub 2009 Mar 24.

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