Drug Information

Drug General Information
Drug ID
D00XJR
Former ID
DIB020106
Drug Name
JNJ-10191584
Synonyms
VUF 6002; JNJ 10191584; VUF6002; VUF-6002; JNJ10191584; compound 12
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527934]
Structure
Download
2D MOL
Formula
C13H15ClN4O
InChI
InChI=1S/C13H15ClN4O/c1-17-4-6-18(7-5-17)13(19)12-15-10-3-2-9(14)8-11(10)16-12/h2-3,8H,4-7H2,1H3,(H,15,16)
InChIKey
MOIWSUQWIOVGRH-UHFFFAOYSA-N
PubChem Compound ID
10446295
PubChem Substance ID
15467241, 24448688, 40573938, 76190029, 85787659, 103452661, 104064558, 125434140, 135649827, 135697737, 137008819, 137412052, 143074736, 152133988, 162648007, 163981447, 172113261, 174316367, 187071963, 198986994, 216088086, 226904595, 245278906, 252160039
Target and Pathway
Target(s) Histamine H4 receptor Target Info Antagonist [527227]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Histamine receptors
G alpha (i) signalling events
WikiPathways GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 527934J Med Chem. 2005 Dec 29;48(26):8289-98.Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists.
Ref 527227Synthesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H(4) receptor antagonists. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5251-6.

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