Drug Information
Drug General Information | |||||
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Drug ID |
D08PDK
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Former ID |
DNC009537
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Drug Name |
1-Bromo-6-(3-hydroxyphenyl)-2-naphthol
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [1] | ||
Structure |
Download2D MOL |
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Formula |
C16H11BrO2
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Canonical SMILES |
C1=CC(=CC(=C1)O)C2=CC3=C(C=C2)C(=C(C=C3)O)Br
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InChI |
1S/C16H11BrO2/c17-16-14-6-4-11(8-12(14)5-7-15(16)19)10-2-1-3-13(18)9-10/h1-9,18-19H
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InChIKey |
WIVQIQQCUPQEGH-UHFFFAOYSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Estradiol 17 beta-dehydrogenase 1 | Target Info | Inhibitor | [1] | |
BioCyc Pathway | Superpathway of steroid hormone biosynthesis | ||||
Estradiol biosynthesis I | |||||
KEGG Pathway | Steroid hormone biosynthesis | ||||
Metabolic pathways | |||||
Ovarian steroidogenesis | |||||
NetPath Pathway | FSH Signaling Pathway | ||||
PANTHER Pathway | Androgen/estrogene/progesterone biosynthesis | ||||
PathWhiz Pathway | Androgen and Estrogen Metabolism | ||||
Reactome | The canonical retinoid cycle in rods (twilight vision) | ||||
WikiPathways | Steroid Biosynthesis | ||||
Metabolism of steroid hormones and vitamin D | |||||
Prostate Cancer | |||||
References | |||||
REF 1 | J Med Chem. 2008 Aug 14;51(15):4685-98. Epub 2008 Jul 17.Substituted 6-phenyl-2-naphthols. Potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1): design, synthesis, biological evaluation, and pharmacokinetics. | ||||
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