Drug Information

Drug General Information
Drug ID
D00UTU
Former ID
DNC007561
Drug Name
7-bromoindirubin-3-acetoxime
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528968]
Structure
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2D MOL

3D MOL
Formula
C18H12BrN3O3
Canonical SMILES
CC(=O)ONC1=C(NC2=CC=CC=C21)C3=C4C=CC=C(C4=NC3=O)Br
InChI
1S/C18H12BrN3O3/c1-9(23)25-22-16-10-5-2-3-8-13(10)20-17(16)14-11-6-4-7-12(19)15(11)21-18(14)24/h2-8,20,22H,1H3
InChIKey
GWCPNAAIJXYZLA-UHFFFAOYSA-N
PubChem Compound ID
11846479
Target and Pathway
Target(s) Aurora protein kinase Target Info Inhibitor [528968]
KEGG Pathway Oocyte meiosis
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteins
References
Ref 528968J Med Chem. 2007 Aug 23;50(17):4027-37. Epub 2007 Aug 1.An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins.
Ref 528968J Med Chem. 2007 Aug 23;50(17):4027-37. Epub 2007 Aug 1.An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins.

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