Drug Information

Drug General Information
Drug ID
D0H6TX
Former ID
DNC007524
Drug Name
(S)-1-(1H-indazol-4-yl)-3-(1-p-tolylethyl)urea
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528843]
Structure
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2D MOL

3D MOL
Formula
C17H18N4O
Canonical SMILES
CC1=CC=C(C=C1)C(C)NC(=O)NC2=CC=CC3=C2C=NN3
InChI
1S/C17H18N4O/c1-11-6-8-13(9-7-11)12(2)19-17(22)20-15-4-3-5-16-14(15)10-18-21-16/h3-10,12H,1-2H3,(H,18,21)(H2,19,20,22)/t12-/m0/s1
InChIKey
SHOUDGQMQHLAFL-LBPRGKRZSA-N
PubChem Compound ID
24768210
Target and Pathway
Target(s) Vanilloid receptor 1 Target Info Inhibitor [528843]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome TRP channels
References
Ref 528843Bioorg Med Chem Lett. 2007 Jul 15;17(14):3894-9. Epub 2007 May 3.Alpha-methylation at benzylic fragment of N-aryl-N'-benzyl ureas provides TRPV1 antagonists with better pharmacokinetic properties and higher efficacy in inflammatory pain model.
Ref 528843Bioorg Med Chem Lett. 2007 Jul 15;17(14):3894-9. Epub 2007 May 3.Alpha-methylation at benzylic fragment of N-aryl-N'-benzyl ureas provides TRPV1 antagonists with better pharmacokinetic properties and higher efficacy in inflammatory pain model.

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