Drug Information

Drug General Information
Drug ID
D06GOE
Former ID
DIB018891
Drug Name
AS74
Synonyms
AS 74; AS-74
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467709]
Structure
Download
2D MOL

3D MOL
Formula
C23H24N6O7
InChI
InChI=1S/C23H24N6O7/c1-3-7-28-21-19(22(31)29(8-4-2)23(28)32)25-20(26-21)16-10-18(27-36-16)33-11-17(30)24-13-5-6-14-15(9-13)35-12-34-14/h5-6,9-10,27H,3-4,7-8,11-12H2,1-2H3,(H,24,30)/b20-16-
InChIKey
JQHDVLXCXBJLFV-SILNSSARSA-N
PubChem Compound ID
10239123
PubChem Substance ID
15241041, 41012545, 78065583, 103207081, 104030500, 135649962, 141440899
Target and Pathway
Target(s) Adenosine A2b receptor Target Info Antagonist [527796]
KEGG Pathway Rap1 signaling pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Alcoholism
NetPath Pathway TGF_beta_Receptor Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database C-MYB transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolism
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 467709(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 439).
Ref 527796Pharmacological characterization of novel adenosine ligands in recombinant and native human A2B receptors. Biochem Pharmacol. 2005 Nov 25;70(11):1601-12. Epub 2005 Oct 10.

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