Drug Information

Drug General Information
Drug ID
D0N9WG
Former ID
DNC007280
Drug Name
N-(4,6-diphenylpyrimidin-2-yl)-3-chlorobenzamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527331]
Structure
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2D MOL

3D MOL
Formula
C23H16ClN3O
Canonical SMILES
C1=CC=C(C=C1)C2=CC(=NC(=N2)NC(=O)C3=CC(=CC=C3)Cl)C4=CC=<br />CC=C4
InChI
1S/C23H16ClN3O/c24-19-13-7-12-18(14-19)22(28)27-23-25-20(16-8-3-1-4-9-16)15-21(26-23)17-10-5-2-6-11-17/h1-15H,(H,25,26,27,28)
InChIKey
BYALFPUQWRIWML-UHFFFAOYSA-N
PubChem Compound ID
11234532
Target and Pathway
Target(s) Adenosine A1 receptor Target Info Inhibitor [527331]
KEGG Pathway cGMP-PKG signaling pathway
cAMP signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
Morphine addiction
NetPath Pathway TCR Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Adenosine P1 receptors
G alpha (i) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 527331J Med Chem. 2004 Dec 16;47(26):6529-40.2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists.
Ref 527331J Med Chem. 2004 Dec 16;47(26):6529-40.2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists.

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