Drug General Information
Drug ID	D0MP8E
Former ID	DIB021203
Drug Name	VUF 8430
Synonyms	VUF8430; VUF-8430
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[538788]
Structure		Download 2D MOL
Formula	C4H11N5S
InChI	InChI=1S/C4H11N5S/c5-3(6)9-1-2-10-4(7)8/h1-2H2,(H3,7,8)(H4,5,6,9)
InChIKey	GSYGTVNTZHFQQH-UHFFFAOYSA-N
PubChem Compound ID	3063228
PubChem Substance ID	36127955, 50112879, 79561405, 111646611, 124968863, 135262187, 135651314, 137143458, 163368467, 247163341
Target and Pathway
Target(s)	Histamine H4 receptor	Target Info	Agonist	[528567]
KEGG Pathway	Neuroactive ligand-receptor interaction
Reactome	Histamine receptors
	G alpha (i) signalling events
WikiPathways	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 538788	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1274).
Ref 528567	Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonist. J Med Chem. 2006 Nov 16;49(23):6650-1.

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