Drug General Information
Drug ID	D00IPO
Former ID	DNC005397
Drug Name	2-(3-Isopropyl-phenyl)-propionic acid
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527602]
Structure		Download 2D MOL 3D MOL
Formula	C12H16O2
Canonical SMILES	CC(C)C1=CC=CC(=C1)C(C)C(=O)O
InChI	1S/C12H16O2/c1-8(2)10-5-4-6-11(7-10)9(3)12(13)14/h4-9H,1-3H3,(H,13,14)
InChIKey	DHFSUPPYOBITGY-UHFFFAOYSA-N
PubChem Compound ID	10307922
Target and Pathway
Target(s)	High affinity interleukin-8 receptor A	Target Info	Inhibitor	[527602]
	High affinity interleukin-8 receptor B	Target Info	Inhibitor	[527602]
KEGG Pathway	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway
	Endocytosis
	Epithelial cell signaling in Helicobacter pylori infectionhsa04060:Cytokine-cytokine receptor interaction
	Epithelial cell signaling in Helicobacter pylori infection
NetPath Pathway	IL2 Signaling PathwayNetPath_9:TNFalpha Signaling Pathway
PANTHER Pathway	Inflammation mediated by chemokine and cytokine signaling pathway
	Interleukin signaling pathwayP00031:Inflammation mediated by chemokine and cytokine signaling pathway
	Interleukin signaling pathway
Pathway Interaction Database	IL8- and CXCR1-mediated signaling eventsil8cxcr2_pathway:IL8- and CXCR2-mediated signaling events
Reactome	Chemokine receptors bind chemokines
	G alpha (i) signalling eventsR-HSA-380108:Chemokine receptors bind chemokines
	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Differentiation Pathway
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like
	GPCRs, Other
References
Ref 527602	J Med Chem. 2005 Jun 30;48(13):4312-31.2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors.
Ref 527602	J Med Chem. 2005 Jun 30;48(13):4312-31.2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors.

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