Drug Information

Drug General Information
Drug ID
D0H9BP
Former ID
DIB021228
Drug Name
xanthine amine congener
Synonyms
papaxac
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540641]
Structure
Download
2D MOL
Formula
C21H28N6O4
InChI
InChI=1S/C21H28N6O4/c1-3-11-26-19-17(20(29)27(12-4-2)21(26)30)24-18(25-19)14-5-7-15(8-6-14)31-13-16(28)23-10-9-22/h5-8H,3-4,9-13,22H2,1-2H3,(H,23,28)(H,24,25)
InChIKey
FIQGIOAELHTLHM-UHFFFAOYSA-N
PubChem Compound ID
5697
PubChem Substance ID
5455855, 7980895, 8153492, 11111969, 14832106, 17405833, 24277745, 29224734, 47217013, 47359839, 47440501, 47805486, 47811001, 50107234, 50107235, 52225234, 53778385, 57322898, 85090417, 85209664, 85231286, 90340726, 92303217, 103579012, 103831832, 104309992, 117540046, 124750378, 124881826, 125165329, 127852773, 134224386, 135080024, 135651217, 135651329, 137014787, 138080078, 139569057, 162091057, 163138682, 163565233, 179151484, 227255507, 245019684, 250129973
Target and Pathway
Target(s) Adenosine A3 receptor Target Info Antagonist [525758]
Adenosine A2b receptor Target Info Antagonist [525667]
Adenosine A1 receptor Target Info Antagonist [533744]
KEGG Pathway Rap1 signaling pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Alcoholismhsa04022:cGMP-PKG signaling pathway
cAMP signaling pathway
Sphingolipid signaling pathway
Morphine addiction
NetPath Pathway TGF_beta_Receptor Signaling Pathway
TCR Signaling PathwayNetPath_11:TCR Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Pathway Interaction Database C-MYB transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome Adenosine P1 receptors
G alpha (i) signalling eventsR-HSA-417973:Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolismR-HSA-417973:Adenosine P1 receptors
G alpha (i) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCRs, OtherWP80:Nucleotide GPCRs
GPCR ligand binding
GPCR downstream signalingWP80:Nucleotide GPCRs
GPCR downstream signaling
References
Ref 540641(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 404).
Ref 525667Use of the triazolotriazine [3H]ZM 241385 as a radioligand at recombinant human A2B adenosine receptors. Drug Des Discov. 1999 Nov;16(3):217-26.
Ref 525758[(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors. Mol Pharmacol. 2000 May;57(5):968-75.
Ref 533744Species difference in the G protein selectivity of the human and bovine A1-adenosine receptor. J Biol Chem. 1994 Dec 23;269(51):32077-84.

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