Drug General Information
Drug ID	D0AT8C
Former ID	DAP000395
Drug Name	Pegfilgrastim
Synonyms	Neulasta; Neulasta (TN); Pegfilgrastim (INN)
Drug Type	Small molecular drug
Indication	Non-myeloid cancer [ICD9: 140-199; ICD10:C00-C75, C7A, C7B]		Approved	[536361], [542001]
Therapeutic Class	Immunomodulatory Agents
Company	Amgen Inc
Structure		Download 2D MOL
Formula	C27H46N4O19
CAS Number	CAS 208265-92-3
PubChem Compound ID	70683024
PubChem Substance ID	49661789
SuperDrug ATC ID	L03AA13
Target and Pathway
Target(s)	Macrophage colony-stimulating factor receptor	Target Info	Binder	[535943]
KEGG Pathway	Cytokine-cytokine receptor interaction
	PI3K-Akt signaling pathway
	Jak-STAT signaling pathway
	Hematopoietic cell lineage
	Pathways in cancer
NetPath Pathway	Leptin Signaling Pathway
	RANKL Signaling Pathway
References
Ref 536361	Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 542001	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6969).
Ref 535943	Evidence that the granulocyte colony-stimulating factor (G-CSF) receptor plays a role in the pharmacokinetics of G-CSF and PegG-CSF using a G-CSF-R KO model. Pharmacol Res. 2004 Jul;50(1):55-8.

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