Drug General Information
Drug ID	D0NX0M
Former ID	DNC006350
Drug Name	3-(6-methoxy-3,4-dihydronaphthalen-2-yl)pyridine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528109]
Structure		Download 2D MOL 3D MOL
Formula	C16H15NO
Canonical SMILES	COC1=CC2=C(C=C1)C=C(CC2)C3=CN=CC=C3
InChI	1S/C16H15NO/c1-18-16-7-6-12-9-13(4-5-14(12)10-16)15-3-2-8-17-11-15/h2-3,6-11H,4-5H2,1H3
InChIKey	WUTGTMFGCHNUET-UHFFFAOYSA-N
PubChem Compound ID	6540049
Target and Pathway
Target(s)	Cytochrome P450 19	Target Info	Inhibitor	[528109]
	Cytochrome P450 11B1, mitochondrial	Target Info	Inhibitor	[529624]
	17 alpha-hydroxylase-C17, 20-lyase	Target Info	Inhibitor	[528109]
BioCyc Pathway	Superpathway of steroid hormone biosynthesis
	Estradiol biosynthesis II
	Estradiol biosynthesis IPWY-7305:Superpathway of steroid hormone biosynthesis
	Glucocorticoid biosynthesis
	Mineralocorticoid biosynthesisPWY-7305:Superpathway of steroid hormone biosynthesis
	Androgen biosynthesis
KEGG Pathway	Steroid hormone biosynthesis
	Metabolic pathways
	Ovarian steroidogenesishsa00140:Steroid hormone biosynthesis
	Metabolic pathwayshsa00140:Steroid hormone biosynthesis
	Ovarian steroidogenesis
	Prolactin signaling pathway
NetPath Pathway	FSH Signaling Pathway
PANTHER Pathway	Androgen/estrogene/progesterone biosynthesis
PathWhiz Pathway	Androgen and Estrogen MetabolismPW000141:SteroidogenesisPW000045:Androgen and Estrogen Metabolism
	Steroidogenesis
Reactome	Endogenous sterolsR-HSA-194002:Glucocorticoid biosynthesis
	Endogenous sterolsR-HSA-193048:Androgen biosynthesis
	Glucocorticoid biosynthesis
	Endogenous sterols
WikiPathways	Metapathway biotransformation
	Tryptophan metabolism
	Oxidation by Cytochrome P450
	Ovarian Infertility Genes
	Metabolism of steroid hormones and vitamin D
	FSH signaling pathway
	Integrated Breast Cancer Pathway
	Phase 1 - Functionalization of compoundsWP702:Metapathway biotransformation
	Corticotropin-releasing hormoneWP702:Metapathway biotransformation
	Steroid Biosynthesis
	Glucocorticoid & Mineralcorticoid Metabolism
	Prostate Cancer
	Phase 1 - Functionalization of compounds
References
Ref 528109	J Med Chem. 2006 Apr 6;49(7):2222-31.Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B2) for the treatment of congestive heart failure and myocardial fibrosis.
Ref 528109	J Med Chem. 2006 Apr 6;49(7):2222-31.Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B2) for the treatment of congestive heart failure and myocardial fibrosis.
Ref 529624	J Med Chem. 2008 Aug 28;51(16):5064-74. Epub 2008 Aug 1.Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization onpotency and selectivity.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.