Drug Information
Drug General Information | |||||
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Drug ID |
D04FEN
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Former ID |
DNC004378
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Drug Name |
KAINATE
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [467567] | ||
Formula |
C10H13NO4-2
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InChI |
InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/p-2/t6-,7+,9-/m0/s1
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InChIKey |
VLSMHEGGTFMBBZ-OOZYFLPDSA-L
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Glutamate receptor, ionotropic kainate 1 | Target Info | Inhibitor | [529560] | |
Glutamate receptor 1 | Target Info | Inhibitor | [529714] | ||
Glutamate receptor AMPA subtype | Target Info | Inhibitor | [529714] | ||
Adenosine A3 receptor | Target Info | Inhibitor | [527823] | ||
KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
Glutamatergic synapsehsa04024:cAMP signaling pathway | |||||
Circadian entrainment | |||||
Long-term potentiation | |||||
Retrograde endocannabinoid signaling | |||||
Glutamatergic synapse | |||||
Dopaminergic synapse | |||||
Long-term depression | |||||
Amyotrophic lateral sclerosis (ALS) | |||||
Amphetamine addiction | |||||
Nicotine addiction | |||||
Pathway Interaction Database | EPHB forward signaling | ||||
WikiPathways | Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellWP666:Hypothetical Network for Drug Addiction | ||||
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||||
Amyotrophic lateral sclerosis (ALS) | |||||
BDNF signaling pathwayWP80:Nucleotide GPCRs | |||||
GPCRs, Class A Rhodopsin-like | |||||
GPCRs, Other | |||||
References | |||||
Ref 527823 | J Med Chem. 2005 Nov 3;48(22):6887-96.2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization. | ||||
Ref 529560 | J Med Chem. 2008 Jul 24;51(14):4093-103. Epub 2008 Jun 25.Chemo-enzymatic synthesis of a series of 2,4-syn-functionalized (S)-glutamate analogues: new insight into the structure-activity relation ofionotropic glutamate receptor subtypes 5, 6, and 7. | ||||
Ref 529714 | J Med Chem. 2008 Oct 23;51(20):6614-8. Epub 2008 Sep 24.1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of potent and Selective iGluR5 modulators. |
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