Drug Information

Drug General Information
Drug ID
D08DQL
Former ID
DIB020568
Drug Name
NPPB
Synonyms
HOE 144; HOE-144
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467607]
Structure
Download
2D MOL

3D MOL
Formula
C16H16N2O4
InChI
InChI=1S/C16H16N2O4/c19-16(20)14-11-13(18(21)22)8-9-15(14)17-10-4-7-12-5-2-1-3-6-12/h1-3,5-6,8-9,11,17H,4,7,10H2,(H,19,20)
InChIKey
WBSMIPAMAXNXFS-UHFFFAOYSA-N
PubChem Compound ID
4549
PubChem Substance ID
586294, 6577388, 7978604, 8150027, 8152803, 11111539, 11113585, 11120005, 11120493, 11120981, 11147088, 11335794, 11361033, 11364722, 11367284, 11369846, 11372794, 11373854, 11378010, 11462005, 11485169, 11489293, 11491333, 11492153, 11495628, 14849531, 17405418, 22391556, 24277859, 26680096, 26681498, 26751788, 26751789, 26751790, 26759252, 29223640, 46487922, 46500489, 47216531, 47736204, 48034834, 48184731, 48258946, 50070434, 50071074, 50104479, 50104480, 50104481, 50104482, 50277869
Target and Pathway
Target(s) ClC-7 Target Info Blocker (channel blocker) [531154]
Chloride channel protein 2 Target Info Blocker (channel blocker) [543920]
Transient receptor potential cation channel subfamily A member 1 Target Info Activator [530784]
VRAC Target Info Blocker (channel blocker) [543931]
calcium activated channel anoctamin 1 Target Info Blocker (channel blocker) [543928]
Maxi Cl- Target Info Blocker (channel blocker) [531154]
KEGG Pathway Mineral absorptionhsa04750:Inflammatory mediator regulation of TRP channels
Reactome Stimuli-sensing channelsR-HSA-3295583:TRP channelsR-HSA-2672351:Stimuli-sensing channels
WikiPathways Iron uptake and transport
References
Ref 467607(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4270).
Ref 530784NPPB structure-specifically activates TRPA1 channels. Biochem Pharmacol. 2010 Jul 1;80(1):113-21.
Ref 531154The G215R mutation in the Cl-/H+-antiporter ClC-7 found in ADO II osteopetrosis does not abolish function but causes a severe trafficking defect. PLoS One. 2010 Sep 7;5(9):e12585.
Ref 543920(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 699).
Ref 543928(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 708).
Ref 543931(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 710).

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