Drug General Information
Drug ID
D0WF7L
Former ID
DCL000499
Drug Name
Brilinta
Synonyms
Brilique; Ticagrelor; AR-C126532; AZD-6140; Ticagrelor (USAN/INN)
Drug Type
Small molecular drug
Indication Thrombosis [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82] Approved [531783], [539115]
Company
AstraZeneca
Structure
Download
2D MOL

3D MOL

Formula
C23H28F2N6O4S
InChI
InChI=1S/C23H28F2N6O4S/c1-2-7-36-23-27-21(26-15-9-12(15)11-3-4-13(24)14(25)8-11)18-22(28-23)31(30-29-18)16-10-17(35-6-5-32)20(34)19(16)33/h3-4,8,12,15-17,19-20,32-34H,2,5-7,9-10H2,1H3,(H,26,27,28)/t12-,15+,16+,17-,19-,20+/m0/s1
InChIKey
OEKWJQXRCDYSHL-FNOIDJSQSA-N
CAS Number
CAS 274693-27-5
PubChem Compound ID
PubChem Substance ID
SuperDrug ATC ID
B01AC24
Target and Pathway
Target(s) P2Y purinoceptor 12 Target Info Antagonist [550288]
KEGG Pathway Platelet activation
Reactome P2Y receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Signal amplification
GPCR ligand binding
GPCR downstream signaling
References
Ref 5317832011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
Ref 539115(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1765).
Ref 550288Clinical pipeline report, company report or official report of AstraZeneca (2009).

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