Drug Information

Drug General Information
Drug ID
D08VXO
Former ID
DAP001066
Drug Name
Brompheniramine
Synonyms
Bromfed; Bromfenex; Bromfeniramina; Brompheniraminum; Brotane; Parabromdylamine; BROMFED-DM; Bromfeniramina [INN-Spanish]; Brompheniramine (INN); Brompheniramine [INN:BAN]; Brompheniraminum [INN-Latin]; Brotane (TN); DIMETANE-DX; P-Bromdylamine; Para-Bromdylamine; Brompheniramine Maleate (1:1); [3-(4-Bromophenyl)-3-(2-pyridyl)propyl]dimethylamine; Gamma-(4-Bromophenyl)-N,N-dimethyl-2-pyridinepropanamine; 1-(p-Bromophenyl)-1-(2-pyridyl)-3-dimethylaminopropane; 2-(p-Bromo-alpha-(2-dimethylaminoethyl)benzyl)pyridine; 3-(4-Bromophenyl)-N,N-dimethyl-3-(2-pyridinyl)-1-propanamine; 3-(4-bromophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine; 3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine; 3-(p-Bromophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine
Drug Type
Small molecular drug
Indication Allergic rhinitis [ICD9: 472.0, 477, 995.3; ICD10:J00, J30, J31.0, T78.4] Approved [538351], [542140]
Therapeutic Class
Antiallergic Agents
Company
Alpharma Us Pharmaceuticals Division
Structure
Download
2D MOL

3D MOL
Formula
C16H19BrN2
InChI
InChI=1S/C16H19BrN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3
InChIKey
ZDIGNSYAACHWNL-UHFFFAOYSA-N
CAS Number
CAS 86-22-6
PubChem Compound ID
6834
PubChem Substance ID
9075, 615216, 6677389, 7978822, 8154449, 10537061, 11342021, 11362204, 11364576, 11367138, 11369700, 11371960, 11374692, 11377862, 11466503, 11467623, 11485355, 11486285, 11487606, 11489426, 11490796, 11492921, 11495496, 15396259, 29225774, 46508137, 47248568, 47397182, 47397183, 47472595, 47472596, 47546820, 47768508, 47991967, 47991968, 48291421, 48415651, 49698955, 50031272, 50065321, 50070760, 50105249, 50892257, 51091865, 85209729, 85788883, 90341200, 92714616, 92729935, 96099913
SuperDrug ATC ID
R06AB01
SuperDrug CAS ID
cas=000086226
Target and Pathway
Target(s) Histamine H1 receptor Target Info Antagonist [537912]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 538351FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 083821.
Ref 542140(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7133).
Ref 537912Histamine-induced venodilation in human beings involves both H1 and H2 receptor subtypes. J Allergy Clin Immunol. 1994 Mar;93(3):606-14.

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