Drug Information

Drug General Information
Drug ID
D0AN7B
Former ID
DAP000429
Drug Name
Melatonin
Synonyms
Circadin; Melapure; Melatol; Melatonex; Melatonina; Melatonine; Melovine; Posidorm; Vivitas; Night Rest; Pineal Hormone; Revital Melatonin; Rx Balance; Sleep Right; IN1244; M 5250; M1105; ML1; MT6; TNP00300; M-1200; M-1250; Mela-T; Melatonex, Melatonin; Melatonina (TN); NMR/14327425; Nature'S Harmony; PREVENTION 2 (MELATONIN); PREVENTION 3 (MELATONIN); PREVENTION 4 (MELATONIN); PREVENTION 5 (MELATONIN); PREVENTION 1 (MELATONIN) (PREVENTION 1); N-Acetyl-5-methoxytryptamine; N-acetyl-5-methoxy-tryptamine; N-[2-(5-methoxyindol-3-yl)ethyl]acetamide; N-(2-(5-Methoxyindol-3-yl)ethyl)acetamide; N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide; Acetamide, {N-[2-(5-methoxyindol-3-yl)ethyl]-}; N-(2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide; Acetamide, N-[2-(5-methoxyindol-3-yl)ethyl]-(6CI,8CI); N-[2-(5-Methoxy-1H-indol-3-yl)-ethyl]-acetamide; Acetamide, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-(9CI); Acetamide, {N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-}; Acetamide, N-(2-(5-methoxy-1H-indol-3-yl)ethyl)-(9CI); 4-ACETAMIDO-4'-ISOTHIO-CYANATOSTILBENE-2,2'-DISULFONIC ACID; 5-Methoxy-N-acetyltryptamine
Drug Type
Small molecular drug
Indication Insomnia [ICD9: 307.41, 307.42, 327.0, 780.51, 780.52; ICD10:F51.0, G47.0] Approved [537181], [539417], [551871]
Therapeutic Class
Central Nervous System Stimulants
Structure
Download
2D MOL

3D MOL
Formula
C13H16N2O2
InChI
InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)
InChIKey
DRLFMBDRBRZALE-UHFFFAOYSA-N
CAS Number
CAS 73-31-4
PubChem Compound ID
896
PubChem Substance ID
2961, 4752, 105815, 410775, 798411, 841969, 893664, 3133753, 4906256, 7636333, 7961516, 7979886, 8144655, 8149639, 8150851, 10321385, 10534170, 10589869, 11111467, 11111468, 11111469, 11221066, 11335528, 11360767, 11363079, 11365641, 11368203, 11372325, 11373730, 11376365, 11408768, 11461739, 11466486, 11467606, 11485263, 11486211, 11489160, 11491208, 11491881, 11493999, 11536797, 11537588, 14773848, 17388930, 17389536, 17405348, 24278103, 24439254, 26612030, 26679682
ChEBI ID
ChEBI:16796
SuperDrug ATC ID
N05CH01
SuperDrug CAS ID
cas=000073314
Target and Pathway
Target(s) Melatonin receptor Target Info Binder [536063], [536104]
KEGG Pathway Neuroactive ligand-receptor interaction
Circadian entrainment
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 537181Melatonin and melatonergic drugs on sleep: possible mechanisms of action. Int J Neurosci. 2009;119(6):821-46.
Ref 539417(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 224).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536063The human MT1 melatonin receptor stimulates cAMP production in the human neuroblastoma cell line SH-SY5Y cells via a calcium-calmodulin signal transduction pathway. J Neuroendocrinol. 2005 Mar;17(3):170-8.
Ref 536104Coexpression of MT1 and RORalpha1 melatonin receptors in the Syrian hamster Harderian gland. J Pineal Res. 2005 Aug;39(1):21-6.

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