Drug Information

Drug General Information
Drug ID
D08VRX
Former ID
DNC000689
Drug Name
GHRP-2
Drug Type
Small molecular drug
Indication Growth hormone deficiency [ICD9: 253.0, 253.3; ICD10:E22.0, E23.0] Approved [551871]
Structure
Download
2D MOL

3D MOL
Formula
C45H55N9O6
Canonical SMILES
CC(C(=O)NC(CC1=CC2=CC=CC=C2C=C1)C(=O)NC(C)C(=O)NC(CC3=C<br />NC4=CC=CC=C43)C(=O)NC(CC5=CC=CC=C5)C(=O)NC(CCCCN)C(=O)N<br />)N
InChI
1S/C45H55N9O6/c1-27(47)41(56)52-38(24-30-19-20-31-14-6-7-15-32(31)22-30)43(58)50-28(2)42(57)53-39(25-33-26-49-35-17-9-8-16-34(33)35)45(60)54-37(23-29-12-4-3-5-13-29)44(59)51-36(40(48)55)18-10-11-21-46/h3-9,12-17,19-20,22,26-28,36-39,49H,10-11,18,21,23-25,46-47H2,1-2H3,(H2,48,55)(H,50,58)(H,51,59)(H,52,56)(H,53,57)(H,54,60)/t27-,28+,36+,37-,38-,39+/m1/s1
InChIKey
HRNLPPBUBKMZMT-RDRUQFPZSA-N
PubChem Compound ID
6918245
PubChem Substance ID
12014785, 14840706, 14913912, 17194766, 43529628, 50458611, 57371849, 103324988, 114787673, 128102836, 134339561, 134340053, 135652164, 152344468, 164830533, 175268741, 226749768, 252543019
Target and Pathway
Target(s) Growth hormone secretagogue receptor type 1 Target Info Agonist [535349]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway Leptin Signaling Pathway
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 535349GH-releasing peptide-2 increases fat mass in mice lacking NPY: indication for a crucial mediating role of hypothalamic agouti-related protein. Endocrinology. 2002 Feb;143(2):558-68.

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