Drug Information

Drug General Information
Drug ID
D02FLB
Former ID
DAP000128
Drug Name
Sodium bicarbonate
Synonyms
Acidosan; Colovage; Glycoprep; Golytely; Jusonin; Meylon; Natriumhydrogenkarbonat; Natron; Neut; Nulytely; Soludal; BSS plus; Baking soda; Bicarbonate of soda; Carbonic acid monosodium salt; Gripe water; Lithium bicarbonate; Monosodium carbonate; Monosodium hydrogen carbonate; Natrii hydrogencarbonas; Natrium bicarbonicum; Natrium hydrogencarbonicum; Natrum bicarbonicum; Sandoz sodium bicarbonate; Sel De vichy; Soda Mint; Sodium acid carbonate; Sodium bicarbonate in plastic container; Sodium bicarbonate liquid concentrate; Sodium bicarbonate solution; Sodium hydrocarbonate; Sodium hydrogen carbonate; Sodium hydrogencarbonate; NaHCO3; Bicarbonate, Sodium; Carbonic acid, monosodium salt; Co-lav; Col-evac; Go-evac; Hema BP-38; Hydrogen Carbonate, Sodium; Meylon (TN); Neut (TN); Peg-lyte; Soda (van); Soda, Baking; Sodium bicarbonate [USAN:JAN]; Carbonic acid sodium salt (1:1); E-Z-EM Prep Lyte; Sodium bicarbonate (1:1); Sodium bicarbonate (JP15/USP); Sodium carbonate (Na(HCO3)); 800 Sodium Bicarbonate Powder
Drug Type
Small molecular drug
Indication Metabolic acidosis [ICD9: 276.2; ICD10:E87.2] Approved [467748], [538505], [551871]
Therapeutic Class
Antidiarrheals
Structure
Download
2D MOL

3D MOL
Formula
CHNaO3
CAS Number
CAS 144-55-8
PubChem Compound ID
516892
PubChem Substance ID
582993, 3133633, 4977523, 7848266, 8147837, 8669758, 10500654, 10501487, 11528438, 15296910, 24848145, 24858955, 24862462, 24865036, 24889074, 24899571, 24899582, 24899673, 24899682, 24899695, 24899739, 24899815, 24899817, 29227583, 46507049, 48414455, 48420011, 50755492, 50755494, 53787141, 57405912, 57647084, 57648561, 57654616, 103446806, 104042946, 109756634, 117376339, 124391975, 125307120, 125311860, 134337450, 134974257, 135091883, 135551762, 137001566, 140077586, 142262832, 143489532, 151975740
ChEBI ID
ChEBI:32139
SuperDrug ATC ID
B05CB04; B05XA02
SuperDrug CAS ID
cas=000144558
Target and Pathway
Target(s) Voltage-dependent T-type calcium channel subunit alpha-1H Target Info Blocker [537336]
Potassiumvoltage-gated channel subfamily D member 3 Target Info Blocker [536860]
KEGG Pathway MAPK signaling pathway
Calcium signaling pathway
Circadian entrainment
PathWhiz Pathway Muscle/Heart ContractionPW000564:Muscle/Heart Contraction
Reactome NCAM1 interactionsR-HSA-1296072:Voltage gated Potassium channels
WikiPathways Corticotropin-releasing hormone
NCAM signaling for neurite out-growthWP2669:Potassium Channels
References
Ref 467748(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4507).
Ref 538505FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 018509.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536860Management of cocaine-induced cardiac arrhythmias due to cardiac ion channel dysfunction. Clin Toxicol (Phila). 2009 Jan;47(1):14-23.
Ref 537336Acute renal failure. Clin Evid (Online). 2008 Sep 3;2008. pii: 2001.

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