Drug Information
Drug General Information | |||||
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Drug ID |
D03DEI
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Former ID |
DAP000794
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Drug Name |
Sulfinpyrazone
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Synonyms |
Anturan; Anturane; Anturanil; Anturano; Anturen; Anturidin; Diphenylpyrazone; Enturan; Enturen; Novopyrazone; Sulfinpirazona; Sulfinpyrazine; Sulfinpyrazon; Sulfinpyrazonum; Sulfoxyphenylpyrazolidin; Sulfoxyphenylpyrazolidine; Sulphinpyrazone; Apo Sulfinpyrazone; Apotex Brand of Sulfinpyrazone; Novartis Brand of Sulfinpyrazone; Nu Pharm Brand of Sulfinpyrazone; Nu Sulfinpyrazone; G 28315; Anturane (TN); Apo-Sulfinpyrazone; G 28,315; Nu-Pharm Brand of Sulfinpyrazone; Nu-Sulfinpyrazone; Sulfinpirazona [INN-Spanish]; Sulfinpyrazone (SPZ); Sulfinpyrazonum [INN-Latin]; USAF GE-13; Sulfinpyrazone [USAN:INN:JAN]; Sulfinpyrazone (JP15/USP/INN); (+/-)-SULFINPYRAZONE; 1,2-Diphenyl-3,5-dioxo-4-(2'-phenyl-sulfinyl-aethyl)-pyrazolidin; 1,2-Diphenyl-3,5-dioxo-4-(2'-phenyl-sulfinyl-aethyl)-pyrazolidin [German]; 1,2-Diphenyl-3,5-dioxo-4-(2-phenylsulfinylethyl) pyrazolidine; 1,2-Diphenyl-3,5-dioxo-4-(2-phenylsulfinylethyl)pyrazolidine; 1,2-Diphenyl-4-(2'-phenylsulfinethyl)-3,5-pyrazolidinedione; 1,2-Diphenyl-4-(2-(phenylsulfinyl)ethyl)-3,5-pyrazolidinedione; 1,2-Diphenyl-4-(phenylsulfinylethyl)-3,5-pyrazolidinedione; 1,2-Diphenyl-4-[2-(phenylsulfinyl)ethyl-3,5-pyrazolidinedione; 1,2-diphenyl-4-[2-(phenylsulfinyl)ethyl]pyrazolidine-3,5-dione; 4-(2-Benzenesulfinylethyl)-1,2-diphenylpyrazolidine-3,5-dione; 4-(Phenylsulfoxyethyl)-1,2-diphenyl-3,5-pyrazolidinedione; 4-[2-(benzenesulfinyl)ethyl]-1,2-diphenylpyrazolidine-3,5-dione
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Drug Type |
Small molecular drug
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Therapeutic Class |
Uricosuric Agents
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Structure |
Download2D MOL |
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Formula |
C23H20N2O3S
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InChI |
InChI=1S/C23H20N2O3S/c26-22-21(16-17-29(28)20-14-8-3-9-15-20)23(27)25(19-12-6-2-7-13-19)24(22)18-10-4-1-5-11-18/h1-15,21H,16-17H2
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InChIKey |
MBGGBVCUIVRRBF-UHFFFAOYSA-N
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CAS Number |
CAS 57-96-5
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PubChem Compound ID | |||||
PubChem Substance ID |
9525, 117338, 611476, 855982, 5632696, 7847515, 8149541, 8153281, 10321460, 11112139, 11335265, 11360504, 11363916, 11366478, 11369040, 11371640, 11374587, 11377202, 11461476, 11466318, 11467438, 11485183, 11486155, 11489140, 11490406, 11492660, 11494836, 14718483, 14879380, 24899841, 26611933, 26680609, 26747070, 26747071, 29224394, 46500625, 46504918, 47216628, 47290983, 47290984, 47440092, 47588838, 48110300, 48334323, 48416577, 49698736, 50029653, 50100985, 50661502, 53789714
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ChEBI ID |
ChEBI:9342
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SuperDrug ATC ID |
M04AB02
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SuperDrug CAS ID |
cas=000057965
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Drug Resistance Mutation (DRM) | |||||
DRM | DRM Info | ||||
Target and Pathway | |||||
Target(s) | Multidrug resistance-associated protein 1 | Target Info | Modulator | [534903], [535143], [536584] | |
NetPath Pathway | IL6 Signaling Pathway | ||||
Pathway Interaction Database | S1P1 pathway | ||||
Sphingosine 1-phosphate (S1P) pathway | |||||
References | |||||
Ref 538448 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 011556. | ||||
Ref 541145 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5826). | ||||
Ref 551871 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
Ref 534903 | Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. Genomics. 1999 Sep 15;60(3):295-308. | ||||
Ref 535143 | Mutation of a single conserved tryptophan in multidrug resistance protein 1 (MRP1/ABCC1) results in loss of drug resistance and selective loss of organic anion transport. J Biol Chem. 2001 May 11;276(19):15616-24. Epub 2001 Feb 21. | ||||
Ref 536584 | Species-dependent transport and modulation properties of human and mouse multidrug resistance protein 2 (MRP2/Mrp2, ABCC2/Abcc2). Drug Metab Dispos. 2008 Apr;36(4):631-40. Epub 2008 Jan 7. |
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