Drug Information

Drug General Information
Drug ID
D0X7XG
Former ID
DAP001008
Drug Name
Fusidic Acid
Synonyms
FUCIDIN; Fucidate; Fucithalmic; Fusidate; Fusidine; Ramycin; Diethanolamine fusidate; Fucidate Sodium; Fucidic acid; Fucidin acid; Fusidate sodium; Fuci (TN); Fucibet (TN); Fucicort (TN); Fucidin (TN); Fucidin Cream 2%; Fucidine (TN); Fucithalmic (TN); Fucizon (TN); Fudic (TN); Fusid (TN); Fusiderm (TN); Fusidin (TN); SQ 16,603; Fusidic acid (USAN/INN); C.A.S. 62,602; (2Z)-2-[(17Z)-16beta-acetoxy-3alpha,11alpha-dihydroxy-4alpha,8alpha,10,14beta-tetramethyl-5alpha,9beta,13alpha-gonan-17-ylidene]-6-methylhept-5-enoic acid; (2Z)-2-[(3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-acetyloxy-3,11-dihydroxy-4,8,10,14-tetramethyl-2,3,4,5,6,7,9,11,12,13,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ylidene]-6-methylhept-5-enoic acid; (2Z)-2-[(3alpha,4alpha,5alpha,8alpha,9beta,11alpha,13alpha,14beta,16beta,17Z)-16-(acetyloxy)-3,11-dihydroxy-4,8,10,14-tetramethylgonan-17-ylidene]-6-methylhept-5-enoic acid; 16-(Acetyloxy)-3,11-dihydroxy-29-nordammara-17(20),24-dien-21-oic acid; 3.alpha.,11.alpha.,16.beta.-Trihydroxy-29-nor-8.alpha.,9.beta.,13.alpha.,14.beta.-dammara-17(20),24-dien-21-oic acid 16-acetate
Drug Type
Small molecular drug
Indication Bacterial infections [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104; ICD10:A00-B99] Approved [536854]
Therapeutic Class
Antibiotics
Company
Leo Laboratories
Structure
Download
2D MOL

3D MOL
Formula
C31H48O6
Canonical SMILES
CC1C2CCC3(C(C2(CCC1O)C)C(CC4C3(CC(C4=C(CCC=C(C)C)C(=O)O<br />)OC(=O)C)C)O)C
InChI
1S/C31H48O6/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36)/b26-20-/t18-,21-,22-,23+,24+,25-,27-,29-,30-,31-/m0/s1
InChIKey
IECPWNUMDGFDKC-MZJAQBGESA-N
CAS Number
CAS 6990-06-3
PubChem Compound ID
3000226
PubChem Substance ID
8919, 105658, 596017, 7979334, 10036127, 24702594, 24894729, 34666341, 46392987, 46505364, 46530473, 47206215, 47736747, 48416045, 49829529, 50959064, 53787526, 56314510, 56320723, 56320724, 57410087, 57654174, 74382570, 87895531, 93576759, 103511436, 109693457, 111610056, 124766024, 124801075, 127344473, 134338277, 134988294, 137004075, 139685296, 160965878, 164814155, 165235893, 175266845, 179230525, 184811991, 223715788, 225067369, 226413683, 241109573, 251916694, 251917933, 251970970, 252350108, 252402473
ChEBI ID
ChEBI:29013
SuperDrug ATC ID
D06AX01; D09AA02; J01XC01; S01AA13
SuperDrug CAS ID
cas=006990063
Target and Pathway
Target(s) Elongation factor G Target Info Inhibitor [537152]
References
Ref 536854Has nature already identified all useful antibacterial targets? Curr Opin Microbiol. 2008 Oct;11(5):387-92. Epub 2008 Oct 6.
Ref 537152Genetic determinants of resistance to fusidic acid among clinical bacteremia isolates of Staphylococcus aureus. Antimicrob Agents Chemother. 2009 May;53(5):2059-65. Epub 2009 Mar 16.

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