Drug General Information
Drug ID	D0L1LJ
Former ID	DIB003273
Drug Name	Bervastatin
Synonyms	LS-2904
Drug Type	Small molecular drug
Indication	Thrombosis [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82]		Discontinued in Phase 2	[545145]
Company	Merck Sante SA
Structure		Download 2D MOL 3D MOL
Formula	C28H31FO5
Canonical SMILES	C1(=C(c2c(OC31CCCC3)cccc2)c1ccc(cc1)F)/C=C/[C@@H](C[C@@<br />H](CC(=O)OCC)O)O
CAS Number	CAS 132017-01-7
PubChem Compound ID	9912369
Target and Pathway
Target(s)	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Target Info	Inhibitor	[526518]
BioCyc Pathway	Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
	Superpathway of cholesterol biosynthesis
	Mevalonate pathway
KEGG Pathway	Terpenoid backbone biosynthesis
	Metabolic pathways
	Biosynthesis of antibiotics
	AMPK signaling pathway
	Bile secretion
NetPath Pathway	IL5 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
	TSH Signaling Pathway
PANTHER Pathway	Cholesterol biosynthesis
PathWhiz Pathway	Steroid Biosynthesis
WikiPathways	Statin Pathway
	Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
	Activation of Gene Expression by SREBP (SREBF)
	SREBF and miR33 in cholesterol and lipid homeostasis
	Integrated Breast Cancer Pathway
	SREBP signalling
	Cholesterol Biosynthesis
References
Ref 545145	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002290)
Ref 526518	Effects of simvastatin, an HMG-CoA reductase inhibitor, in patients with hypertriglyceridemia. Clin Cardiol. 2003 Jan;26(1):18-24.

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