Drug Information

Drug General Information
Drug ID
D0J2UW
Former ID
DNC000411
Drug Name
CGS 21680
Drug Type
Small molecular drug
Indication Discovery agent Terminated [540510], [544564]
Structure
Download
2D MOL

3D MOL
Formula
C23H29N7O6
InChI
InChI=1S/C23H29N7O6/c1-2-25-21(35)18-16(33)17(34)22(36-18)30-11-27-15-19(24)28-23(29-20(15)30)26-10-9-13-5-3-12(4-6-13)7-8-14(31)32/h3-6,11,16-18,22,33-34H,2,7-10H2,1H3,(H,25,35)(H,31,32)(H3,24,26,28,29)/t16-,17+,18-,22+/m0/s1
InChIKey
PAOANWZGLPPROA-RQXXJAGISA-N
CAS Number
CAS 124182-57-6
PubChem Compound ID
3086599
PubChem Substance ID
7978912, 10748414, 14859889, 24263018, 36416348, 49881014, 50104707, 53790868, 57356012, 78010568, 85856597, 90341157, 103342361, 103980562, 111695205, 128888237, 134341772, 135061368, 135650083, 135651144, 139543640, 140916706, 144233173, 144233174, 152258457, 160647293, 162169286, 162220816, 179590195, 185975553, 198970009, 224517877, 227013111, 249814827, 249814828, 249814829, 252333367
Target and Pathway
Target(s) Adenosine A2a receptor Target Info Agonist [535415]
KEGG Pathway Rap1 signaling pathway
Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Parkinson's disease
Alcoholism
Pathway Interaction Database HIF-2-alpha transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Reactome NGF-independant TRKA activation
Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolism
WikiPathways Nucleotide GPCRs
Monoamine Transport
GPCRs, Class A Rhodopsin-like
NGF signalling via TRKA from the plasma membrane
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 540510(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 375).
Ref 544564Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000147)
Ref 535415Effects of CGS 21680, a selective adenosine A2A receptor agonist, on allergic airways inflammation in the rat. Eur J Pharmacol. 2002 Mar 8;438(3):183-8.

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