Drug General Information
Drug ID	D03RGO
Former ID	DIB005110
Drug Name	CP-331
Synonyms	CP-6
Drug Type	Small molecular drug
Indication	Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89]		Terminated	[544979]
Company	Zeria Pharmaceutical Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C38H44ClN3O6S
Canonical SMILES	n1(c(c(c2c1ccc(c2)OC)CC(=O)OCCSCC(=O)NCCCOc1cc(CN2CCCCC<br />2)ccc1)C)C(=O)c1ccc(cc1)Cl
CAS Number	CAS 127966-70-5
PubChem Compound ID	130967
Target and Pathway
Target(s)	Histamine H2 receptor	Target Info	Modulator	[531237]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gastric acid secretion
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Histamine H2 receptor mediated signaling pathway
PathWhiz Pathway	Intracellular Signalling Through Histamine H2 Receptor and Histamine
	Gastric Acid Production
Reactome	Histamine receptors
	G alpha (s) signalling events
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Secretion of Hydrochloric Acid in Parietal Cells
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 544979	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001767)
Ref 531237	Conjugation of chlorin p(6) to histamine enhances its cellular uptake and phototoxicity in oral cancer cells. Cancer Chemother Pharmacol. 2011 Aug;68(2):359-69.

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