Drug General Information
Drug ID	D0P0TR
Former ID	DIB006496
Drug Name	Meluadrine
Synonyms	Meluadrine tartrate; HSR-81
Drug Type	Small molecular drug
Indication	Premature ejaculation [ICD9: 302.75; ICD10:F52.4]		Discontinued in Preregistration	[545398]
Company	Hokuriku Seiyaku KK
Structure		Download 2D MOL 3D MOL
Formula	C12H18ClNO2
Canonical SMILES	C(NC[C@@H](c1c(cc(cc1)O)Cl)O)(C)(C)C
CAS Number	CAS 134865-37-5
PubChem Compound ID	3045414
Target and Pathway
Target(s)	Beta-2 adrenergic receptor	Target Info	Modulator	[526451]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Endocytosis
	Adrenergic signaling in cardiomyocytes
	Salivary secretion
NetPath Pathway	TCR Signaling Pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Beta2 adrenergic receptor signaling pathway
Pathway Interaction Database	Arf6 trafficking events
	Arf6 signaling events
Reactome	Adrenoceptors
	G alpha (s) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	Vitamin D Receptor Pathway
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 545398	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003111)
Ref 526451	Effects of meluadrine tartrate and ritodrine hydrochloride on oxytocin-induced uterine contraction, uterine arterial blood flow and maternal cardiovascular function in pregnant goats. Jpn J Pharmacol. 2002 Oct;90(2):107-13.

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