Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0HK7R
|
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| Former ID |
DIB012734
|
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| Drug Name |
Midafotel
|
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| Synonyms |
EAA-494; D-CPP-ene; SDZ-EAA-494
|
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| Drug Type |
Small molecular drug
|
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| Indication | Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10:F01-F07, F04, F05, R41.3] | Discontinued in Phase 3 | [1] | ||
| Company |
BTG plc
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C8H15N2O5P
|
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| Canonical SMILES |
P(=O)(/C=C/CN1C[C@H](C(=O)O)NCC1)(O)O
|
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| CAS Number |
CAS 117414-74-1
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | NMDA receptor | Target Info | Modulator | [2] | |
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002722) | ||||
| REF 2 | D-CPP-ene (SDZ EAA 494), a potent and competitive N-methyl-D-aspartate (NMDA) antagonist: effect on spontaneous activity and NMDA-induced depolarizations in the rat neocortical slice preparation, compared with other CPP derivatives and MK-801. Neurosci Lett. 1990 Jun 8;113(3):315-21. | ||||
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