Drug General Information
Drug ID
D0N0PU
Former ID
DCL000155
Drug Name
LTB 019
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Discontinued in Phase 2 [547374]
Company
Novartis
Structure
Download
2D MOL

3D MOL

Formula
C25H35N3O4
Canonical SMILES
CC(C)N(C(C)C)C(=O)C1=CC(=C(C=C1)OCCCCCOC2=CC=C(C=C2)C(=<br />N)N)O
InChI
1S/C25H35N3O4/c1-17(2)28(18(3)4)25(30)20-10-13-23(22(29)16-20)32-15-7-5-6-14-31-21-11-8-19(9-12-21)24(26)27/h8-13,16-18,29H,5-7,14-15H2,1-4H3,(H3,26,27)
InChIKey
LBVCAMSVLTWBRT-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Leukotriene B4 receptor 1 Target Info Antagonist [536562]
KEGG Pathway Neuroactive ligand-receptor interaction
NetPath Pathway IL4 Signaling Pathway
Reactome Leukotriene receptors
G alpha (q) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Spinal Cord Injury
GPCR ligand binding
GPCR downstream signaling
References
Ref 547374Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015581)
Ref 536562Effect of the oral leukotriene B4 receptor antagonist LTB019 on inflammatory sputum markers in patients with chronic obstructive pulmonary disease. Pulm Pharmacol Ther. 2008;21(2):409-17.

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