Drug Information

Drug General Information
Drug ID
D01KHX
Former ID
DIB000262
Drug Name
Rilmakalim
Synonyms
Hoe-234
Drug Type
Small molecular drug
Indication Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10:J40-J44, J47] Discontinued in Phase 1 [544828]
Company
Hoechst AG
Structure
Download
2D MOL

3D MOL
Formula
C21H23NO5S
Canonical SMILES
S(=O)(=O)(c1cc2[C@@H](N3C(=O)CCC3)[C@@H](C(Oc2cc1)(C)C)<br />O)c1ccccc1
CAS Number
CAS 132014-21-2
PubChem Compound ID
65966
Target and Pathway
Target(s) Potassium channel Target Info Opener [527119]
References
Ref 544828Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001252)
Ref 527119Hypotonic stress increases efficacy of rilmakalim, but not pinacidil, to activate ATP-sensitive K(+) current in guinea pig ventricular myocytes. J Pharmacol Sci. 2004 Jun;95(2):189-95.

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