Drug General Information
Drug ID	D07DBS
Former ID	DIB005076
Drug Name	RP-64477
Indication	Hyperlipidaemia [ICD9: 272.0-272.4; ICD10:E78]		Discontinued in Phase 2	[545150]
Company	Rhone-Poulenc SA
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C(=O)(Nc1cc(C(=O)NCCCC)ccc1SC)c1ccc(cc1)OCCCCCCCCCC
CAS Number	CAS 135239-65-5
Target and Pathway
Target(s)	Liver carboxylesterase	Target Info	Modulator	[534116]
KEGG Pathway	Drug metabolism - other enzymes
	Metabolic pathways
Pathway Interaction Database	E2F transcription factor network
WikiPathways	NRF2 pathway
	Nuclear Receptors Meta-Pathway
	Heroin metabolism
	Irinotecan Pathway
	Fluoropyrimidine Activity
	Phase I biotransformations, non P450
References
Ref 545150	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002301)
Ref 534116	RP 64477: a potent inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase with low systemic bioavailability. Biochem Pharmacol. 1996 Feb 23;51(4):413-21.

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