Drug General Information
Drug ID	D06MPF
Former ID	DIB009200
Drug Name	Sch-40120
Drug Type	Small molecular drug
Indication	Pruritus [ICD9: 698; ICD10:L29]		Terminated	[545555]
Company	Schering-Plough Corp
Structure		Download 2D MOL 3D MOL
Formula	C18H15ClN2O
Canonical SMILES	n1(c2c(c(=O)c3c1CCCC3)cccn2)c1cc(Cl)ccc1
CAS Number	CAS 110545-79-4
PubChem Compound ID	3081026
Target and Pathway
Target(s)	Arachidonate 5-lipoxygenase	Target Info	Modulator	[526810]
BioCyc Pathway	Aspirin-triggered lipoxin biosynthesis
	Resolvin D biosynthesis
	Leukotriene biosynthesis
	Lipoxin biosynthesis
	Aspirin triggered resolvin D biosynthesis
	Aspirin triggered resolvin E biosynthesis
KEGG Pathway	Arachidonic acid metabolism
	Metabolic pathways
	Serotonergic synapse
	Ovarian steroidogenesis
	Toxoplasmosis
NetPath Pathway	IL4 Signaling Pathway
PathWhiz Pathway	Arachidonic Acid Metabolism
WikiPathways	Vitamin D Receptor Pathway
	Arachidonic acid metabolism
	Eicosanoid Synthesis
	Selenium Micronutrient Network
References
Ref 545555	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003693)
Ref 526810	Actions of a 5-lipoxygenase inhibitor, Sch 40120, on acute inflammatory responses. J Pharmacol Exp Ther. 1992 Aug;262(2):721-8.

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