Drug General Information
Drug ID	D08ZBT
Former ID	DIB015536
Drug Name	SDZ-WAG-994
Synonyms	WAG-994
Drug Type	Small molecular drug
Indication	Hypertension [ICD9: 401; ICD10:I10-I16]		Discontinued in Phase 1	[545500]
Company	Novartis AG
Structure		Download 2D MOL 3D MOL
Formula	C17H25N5O4
Canonical SMILES	n1([C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)OC)c2c(nc1)c(ncn2)<br />NC1CCCCC1
CAS Number	CAS 130714-47-5
PubChem Compound ID	18755269
Target and Pathway
Target(s)	Adenosine A1 receptor	Target Info	Agonist	[533841]
KEGG Pathway	cGMP-PKG signaling pathway
	cAMP signaling pathway
	Sphingolipid signaling pathway
	Neuroactive ligand-receptor interaction
	Morphine addiction
NetPath Pathway	TCR Signaling Pathway
	RANKL Signaling Pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome	Adenosine P1 receptors
	G alpha (i) signalling events
WikiPathways	Nucleotide GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545500	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003507)
Ref 533841	The cardiac effects of a novel A1-adenosine receptor agonist in guinea pig isolated heart. J Pharmacol Exp Ther. 1994 Dec;271(3):1371-82.

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