Drug Information

Drug General Information
Drug ID
D07UGA
Former ID
DNC010688
Drug Name
Sphingosine-1-phosphate
Drug Type
Small molecular drug
Indication Acne vulgaris [ICD9: 706.1; ICD10:L70.0] Phase 1 [523681], [543301]
Structure
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2D MOL

3D MOL
Formula
C18H38NO5P
InChI
InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1
InChIKey
DUYSYHSSBDVJSM-KRWOKUGFSA-N
PubChem Compound ID
5283560
PubChem Substance ID
8381, 841938, 3153153, 4266347, 11039024, 11538026, 14853517, 14902393, 24893757, 24899853, 26754964, 26754965, 26759550, 29214822, 39316963, 47736194, 50069271, 53790239, 56310719, 56314086, 56314115, 57358934, 79196702, 85230694, 91616005, 99431555, 103513044, 104045126, 104046551, 112629138, 113860431, 123055038, 135061792, 135651563, 137123351, 141225271, 144107094, 162223883, 163687305, 164808502, 175443701, 179205494, 226395983, 228659508, 241182370, 241375387, 250135272, 252467313
Target and Pathway
Target(s) Sphingosine 1-phosphate receptor 1 Target Info Inhibitor [530799]
KEGG Pathway FoxO signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
IL2 Signaling Pathway
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
S1P3 pathway
S1P1 pathway
Sphingosine 1-phosphate (S1P) pathway
PDGFR-beta signaling pathway
Reactome G alpha (i) signalling events
Lysosphingolipid and LPA receptors
WikiPathways Signal Transduction of S1P Receptor
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 523681ClinicalTrials.gov (NCT01466322) A Study to Assess the Relative Bioavailability of Different Formulations of GSK2018682, a Sphingosine-1-phosphate Receptor Subtype 1 Agonist, in Healthy Volunteers.. U.S. National Institutes of Health.
Ref 543301(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 911).
Ref 530799Bioorg Med Chem Lett. 2010 Apr 15;20(8):2520-4. Epub 2010 Mar 3.Exploration of amino alcohol derivatives as novel, potent, and highly selective sphingosine-1-phosphate receptor subtype-1 agonists.

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