Drug Information

Drug General Information
Drug ID
D0E9EE
Former ID
DCL000232
Drug Name
SR 144190
Synonyms
SR-144190; 3-(1-(2-(4-benzoyl-2-(3,4-difluorophenyl)morpholin-2-yl)ethyl)-4-phenylpiperidin-4-yl)-1-dimethylurea
Drug Type
Small molecular drug
Indication Depression; Acute or chronic pain; Anxiety disorders; Urinary incontinence [ICD9: 300, 311, 338, 338.2, 787.6, 788.3,780; ICD10:F30-F42, N39.3-N39.4, G89] Discontinued in Phase 1 [546499]
Therapeutic Class
Analgesics
Company
Sanofi-aventis
Structure
Download
2D MOL

3D MOL
Formula
C33H38F2N4O3
Canonical SMILES
CN(C)C(=O)NC1(CCN(CC1)CCC2(CN(CCO2)C(=O)C3=CC=CC=C3)C4=<br />CC(=C(C=C4)F)F)C5=CC=CC=C5
InChI
1S/C33H38F2N4O3/c1-37(2)31(41)36-32(26-11-7-4-8-12-26)15-18-38(19-16-32)20-17-33(27-13-14-28(34)29(35)23-27)24-39(21-22-42-33)30(40)25-9-5-3-6-10-25/h3-14,23H,15-22,24H2,1-2H3,(H,36,41)
InChIKey
QNLIUVLFRVYNCV-UHFFFAOYSA-N
PubChem Compound ID
9810217
PubChem Substance ID
14911285, 24116694, 44846204, 79137203, 85221960, 129048248, 142061362, 229139127
Target and Pathway
Target(s) NK-2 receptor Target Info Antagonist [535777], [535994]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Reactome G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 546499Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008589)
Ref 535777Antagonists at the neurokinin receptors--recent patent literature. IDrugs. 2003 Aug;6(8):758-72.
Ref 535994Pharmacologic evaluation of neurokinin-2 receptor antagonists in the guinea pig respiratory tract. Am J Vet Res. 2004 Jul;65(7):984-91.

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