Drug General Information
Drug ID	D0L3YX
Former ID	DCL001009
Drug Name	T-62
Drug Type	Small molecular drug
Indication	Neuropathic pain [ICD9: 356.0, 356.8; ICD10:G64, G90.0]		Discontinued in Phase 1	[536374]
Therapeutic Class	Analgesics
Company	King Pharmaceuticals
Structure		Download 2D MOL 3D MOL
Formula	C15H14ClNOS
Canonical SMILES	C1CCC2=C(C1)C(=C(S2)N)C(=O)C3=CC=C(C=C3)Cl
InChI	1S/C15H14ClNOS/c16-10-7-5-9(6-8-10)14(18)13-11-3-1-2-4-12(11)19-15(13)17/h5-8H,1-4,17H2
InChIKey	OTZVBZFYMFTYKH-UHFFFAOYSA-N
CAS Number	CAS 40312-34-3
PubChem Compound ID	855908
PubChem Substance ID	1098498, 4020521, 5015910, 9168380, 14751361, 24724635, 29217669, 45844128, 47487200, 48381677, 50399255, 57408860, 89010306, 103247988, 103857411, 103980695, 105138250, 110006724, 117526639, 118265374, 124582506, 128861724, 130961476, 131359574, 142419830, 162248528, 162943975, 163640238, 167756202, 198972600, 225223475, 226503353, 241088364, 252450807
Target and Pathway
Target(s)	Adenosine A2a receptor	Target Info	Antagonist	[536374]
KEGG Pathway	Rap1 signaling pathway
	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Vascular smooth muscle contraction
	Parkinson's disease
	Alcoholism
Pathway Interaction Database	HIF-2-alpha transcription factor network
PathWhiz Pathway	Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Reactome	NGF-independant TRKA activation
	Adenosine P1 receptors
	G alpha (s) signalling events
	Surfactant metabolism
WikiPathways	Nucleotide GPCRs
	Monoamine Transport
	GPCRs, Class A Rhodopsin-like
	NGF signalling via TRKA from the plasma membrane
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 536374	Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26.
Ref 536374	Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26.

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