Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D05HZI
|
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| Former ID |
DNC000918
|
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| Drug Name |
MDL 101,731
|
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| Drug Type |
Small molecular drug
|
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| Indication | Gastric cancer [ICD9: 151; ICD10:C16] | Discontinued in Phase 2 | [545234] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C10H12FN3O4
|
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| Canonical SMILES |
C1=CN(C(=O)N=C1N)C2C(=CF)C(C(O2)CO)O
|
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| InChI |
1S/C10H12FN3O4/c11-3-5-8(16)6(4-15)18-9(5)14-2-1-7(12)13-10(14)17/h1-3,6,8-9,15-16H,4H2,(H2,12,13,17)/b5-3+/t6-,8+,9-/m1/s1
|
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| InChIKey |
GFFXZLZWLOBBLO-ASKVSEFXSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Ribonucleoside-diphosphatereductase subunit M2 | Target Info | Modulator | ||
| BioCyc Pathway | Pyrimidine deoxyribonucleotides biosynthesis from CTP | ||||
| Pyrimidine deoxyribonucleotides de novo biosynthesis | |||||
| Guanosine nucleotides de novo biosynthesis | |||||
| Superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis | |||||
| Superpathway of purine nucleotide salvage | |||||
| Purine nucleotides de novo biosynthesis | |||||
| Adenosine deoxyribonucleotides de novo biosynthesis | |||||
| Guanosine deoxyribonucleotides de novo biosynthesis | |||||
| NetPath Pathway | EGFR1 Signaling Pathway | ||||
| Pathway Interaction Database | E2F transcription factor network | ||||
| PathWhiz Pathway | Purine Metabolism | ||||
| Pyrimidine Metabolism | |||||
| References | |||||
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