Drug General Information
Drug ID	D0X8QI
Former ID	DIB006689
Drug Name	UP-116-77
Synonyms	Mipitroban
Drug Type	Small molecular drug
Indication	Thromboembolism [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82]		Terminated	[545861]
Company	Laboratories UPSA
Structure		Download 2D MOL 3D MOL
Formula	C19H19Cl2N3O2
Canonical SMILES	n1(c(nc2c1ncc(c2)Cl)CC(C(=O)O)(C)C)Cc1ccc(Cl)cc1
CAS Number	CAS 136122-46-8
PubChem Compound ID	3086644
Target and Pathway
Target(s)	Thromboxane A2 receptor	Target Info	Modulator	[534051]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Platelet activation
Reactome	Prostanoid ligand receptors
	G alpha (q) signalling events
	G alpha (12/13) signalling events
	Thromboxane signalling through TP receptor
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Small Ligand GPCRs
	Signal amplification
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545861	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005083)
Ref 534051	Synthesis and structure-activity relationships of novel benzimidazole and imidazo[4,5-b]pyridine acid derivatives as thromboxane A2 receptor antagonists. J Med Chem. 1993 Apr 30;36(9):1175-87.

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