Drug Information

Drug General Information
Drug ID
D07JTD
Former ID
DNC010754
Drug Name
NSC-645809
Drug Type
Small molecular drug
Indication Breast cancer [ICD9: 174, 175; ICD10:C50] Phase 2 [531934]
Structure
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2D MOL

3D MOL
Formula
C20H26Cl2N4O3
Canonical SMILES
CCN(CC)CCNC1=C2C3=C(C=C1)N=CN3C4=C(C2=O)C=C(C=C4)O.O.Cl<br />.Cl
InChI
1S/C20H22N4O2.2ClH.H2O/c1-3-23(4-2)10-9-21-15-6-7-16-19-18(15)20(26)14-11-13(25)5-8-17(14)24(19)12-22-16;;;/h5-8,11-12,21,25H,3-4,9-10H2,1-2H3;2*1H;1H2
InChIKey
XJYNBZQTAZDMHZ-UHFFFAOYSA-N
PubChem Compound ID
6918316
Target and Pathway
Target(s) NRH dehydrogenase [quinone] 2 Target Info Inhibitor [530820]
References
Ref 531934Role of human UDP-glucuronosyltransferases in the biotransformation of the triazoloacridinone and imidazoacridinone antitumor agents C-1305 and C-1311: highly selective substrates for UGT1A10. Drug Metab Dispos. 2012 Sep;40(9):1736-43.
Ref 530820Bioorg Med Chem Lett. 2010 May 1;20(9):2832-6. Epub 2010 Mar 15.Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2.

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