TTD | Drug: D0IZ7T

Drug General Information
Drug ID	D0IZ7T
Former ID	DIB010733
Drug Name	YM-17E
Drug Type	Small molecular drug
Indication	Hyperlipidaemia [ICD9: 272.0-272.4; ICD10:E78]		Discontinued in Phase 1	[545258]
Company	Yamanouchi Pharmaceutical Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C40H58Cl2N6O2
Canonical SMILES	C(=O)(N(Cc1cc(CN(C(=O)Nc2ccc(N(C)C)cc2)C2CCCCCC2)ccc1)C<br />1CCCCCC1)Nc1ccc(N(C)C)cc1.Cl.Cl
CAS Number	CAS 124884-99-7
PubChem Compound ID	180288
Target and Pathway
Target(s)	Liver carboxylesterase	Target Info	Modulator	[534326]
KEGG Pathway	Drug metabolism - other enzymes
KEGG Pathway	Metabolic pathways
Pathway Interaction Database	E2F transcription factor network
WikiPathways	NRF2 pathway
	Nuclear Receptors Meta-Pathway
	Heroin metabolism
	Irinotecan Pathway
	Fluoropyrimidine Activity
	Phase I biotransformations, non P450
References
Ref 545258	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002618)
Ref 534326	Pharmacological properties of YM17E, an acyl-CoA:cholesterol acyltransferase inhibitor, and diarrheal effect in beagle dogs. Jpn J Pharmacol. 1997 Jan;73(1):41-50.

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Drug Information