Drug General Information
Drug ID
D00UCW
Former ID
DIB014405
Drug Name
CEREBROCRAST
Synonyms
IOS-1.1212; 4-[2-(Difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid di(2-propoxyethyl) diester
Drug Type
Small molecular drug
Indication Nerve injury [ICD10:T14.4] Discontinued in Phase 1 [546142]
Structure
Download
2D MOL

3D MOL

Formula
C26H35F2NO7
Canonical SMILES
CCCOCCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2OC(F)F)C(=O)OCCOCCC<br />)C)C
InChI
1S/C26H35F2NO7/c1-5-11-32-13-15-34-24(30)21-17(3)29-18(4)22(25(31)35-16-14-33-12-6-2)23(21)19-9-7-8-10-20(19)36-26(27)28/h7-10,23,26,29H,5-6,11-16H2,1-4H3
InChIKey
ASCWBYZMMHUZMQ-UHFFFAOYSA-N
CAS Number
CAS 108863-62-3
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Calcium channel Target Info Inhibitor [530538], [551871]
References
Ref 546142Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006562)
Ref 530538The dihydropyridine analogue cerebrocrast blocks both T-type and L-type calcium currents. Can J Physiol Pharmacol. 2009 Nov;87(11):923-32.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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