Drug Information

Drug General Information
Drug ID
D04PSL
Former ID
DIB011118
Drug Name
FINROZOLE
Synonyms
MPV-2213ad; Finrozole < Prop INN >; Rac-(R*,S*)-4-[3-(4-Fluorophenyl)-2-hydroxy-1-(1,2,4-triazol-1-yl)propyl]benzonitrile
Drug Type
Small molecular drug
Indication Prostate disease [ICD10:N42.9] Discontinued in Phase 2 [546744]
Structure
Download
2D MOL

3D MOL
Formula
C18H15FN4O
Canonical SMILES
OC(Cc1ccc(F)cc1)C(c2ccc(cc2)C#N)n3cncn3
InChI
1S/C18H15FN4O/c19-16-7-3-13(4-8-16)9-17(24)18(23-12-21-11-22-23)15-5-1-14(10-20)2-6-15/h1-8,11-12,17-18,24H,9H2
InChIKey
SLJZVZKQYSKYNV-UHFFFAOYSA-N
CAS Number
CAS 160146-17-8
PubChem Compound ID
6918277
Target and Pathway
Target(s) Cytochrome P450 19 Target Info Inhibitor [526217], [551871]
BioCyc Pathway Superpathway of steroid hormone biosynthesis
Estradiol biosynthesis II
Estradiol biosynthesis I
KEGG Pathway Steroid hormone biosynthesis
Metabolic pathways
Ovarian steroidogenesis
NetPath Pathway FSH Signaling Pathway
PANTHER Pathway Androgen/estrogene/progesterone biosynthesis
PathWhiz Pathway Androgen and Estrogen Metabolism
Reactome Endogenous sterols
WikiPathways Metapathway biotransformation
Tryptophan metabolism
Oxidation by Cytochrome P450
Ovarian Infertility Genes
Metabolism of steroid hormones and vitamin D
FSH signaling pathway
Integrated Breast Cancer Pathway
Phase 1 - Functionalization of compounds
References
Ref 546744Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010074)
Ref 526217Pharmacokinetics of finrozole (MPV-2213ad), a novel selective aromatase inhibitor, in healthy men. Br J Clin Pharmacol. 2001 Dec;52(6):702-4.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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