Drug Information

Drug General Information
Drug ID
D0U5NU
Former ID
DIB016533
Drug Name
GLENVASTATIN
Synonyms
HR-780; Glenvastatin < Rec INN >; [4(R),6(S),(E)]-6-[2-[4-(4-Fluorophenyl)-2-isopropyl-6-phenyl-3-pyridyl]vinyl]-4-hydroxytetrahydropyran-2-one
Drug Type
Small molecular drug
Indication Hyperlipidaemia [ICD9: 272.0-272.4; ICD10:E78] Discontinued in Phase 2 [544823]
Structure
Download
2D MOL

3D MOL
Formula
C27H26FNO3
Canonical SMILES
CC(C)c1nc(cc(c1\\C=C\\[C@H]2C[C@H](O)CC(=O)O2)c3ccc(F)c<br />c3)c4ccccc4
InChI
1S/C27H26FNO3/c1-17(2)27-23(13-12-22-14-21(30)15-26(31)32-22)24(18-8-10-20(28)11-9-18)16-25(29-27)19-6-4-3-5-7-19/h3-13,16-17,21-22,30H,14-15H2,1-2H3/b13-12+/t21-,22-/m0/s1
InChIKey
LJIZUXQINHXGAO-WYCPQIHASA-N
CAS Number
CAS 122254-45-9
PubChem Compound ID
5281970
Target and Pathway
Target(s) 3-hydroxy-3-methylglutaryl-coenzyme A reductase Target Info Inhibitor [533833], [551871]
BioCyc Pathway Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
Superpathway of cholesterol biosynthesis
Mevalonate pathway
KEGG Pathway Terpenoid backbone biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
AMPK signaling pathway
Bile secretion
NetPath Pathway IL5 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
TSH Signaling Pathway
PANTHER Pathway Cholesterol biosynthesis
PathWhiz Pathway Steroid Biosynthesis
WikiPathways Statin Pathway
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Activation of Gene Expression by SREBP (SREBF)
SREBF and miR33 in cholesterol and lipid homeostasis
Integrated Breast Cancer Pathway
SREBP signalling
Cholesterol Biosynthesis
References
Ref 544823Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001230)
Ref 533833Bile acid derived HMG-CoA reductase inhibitors. Biochim Biophys Acta. 1994 Nov 29;1227(3):137-54.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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