Drug Information

Drug General Information
Drug ID
D0Z0OT
Former ID
DIB011240
Drug Name
ONO-4057
Synonyms
Ono-LB-457; 5-[2-(2-Carboxyethyl)-3-[6-(4-methoxyphenyl)-5(E)-hexenyloxy]phenoxy]pentanoic acid
Drug Type
Small molecular drug
Indication Inflammatory bowel disease [ICD9: 555, 556; ICD10:K50, K51] Discontinued in Phase 2 [541347], [545386]
Structure
Download
2D MOL

3D MOL
Formula
C27H34O7
InChI
InChI=1S/C27H34O7/c1-32-22-15-13-21(14-16-22)9-4-2-3-6-19-33-24-10-8-11-25(23(24)17-18-27(30)31)34-20-7-5-12-26(28)29/h4,8-11,13-16H,2-3,5-7,12,17-20H2,1H3,(H,28,29)(H,30,31)/b9-4+
InChIKey
JOPSSWGWLCLPPF-RUDMXATFSA-N
CAS Number
CAS 134578-96-4
PubChem Compound ID
6438358
PubChem Substance ID
11968043, 14858600, 43031366, 50070478, 50071119, 57368014, 76004646, 99222759, 103297162, 103944929, 114555920, 135077965, 142780709, 144232889, 178102778, 179294168, 226490838
Target and Pathway
Target(s) Leukotriene B4 receptor 2 Target Info Modulator [526760]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Reactome Leukotriene receptors
G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 541347(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6157).
Ref 545386Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003085)
Ref 526760ONO-4057, a novel, orally active leukotriene B4 antagonist: effects on LTB4-induced neutrophil functions. Prostaglandins. 1992 Oct;44(4):261-75.

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