Drug Information

Drug General Information
Drug ID
D0D8FN
Former ID
DCL000324
Drug Name
LY-156735
Synonyms
LY 156735; N-[(2r)-2-(6-chloro-5-methoxy-1h-indol-3-yl)propyl]acetamide
Drug Type
Small molecular drug
Indication Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] Phase 2 [529024], [538829]
Company
Phase 2 Discovery
Structure
Download
2D MOL

3D MOL
Formula
C14H17ClN2O2
InChI
InChI=1S/C14H17ClN2O2/c1-8(6-16-9(2)18)11-7-17-13-5-12(15)14(19-3)4-10(11)13/h4-5,7-8,17H,6H2,1-3H3,(H,16,18)/t8-/m0/s1
InChIKey
RKHCTAKUYDTFHE-QMMMGPOBSA-N
CAS Number
CAS 118702-11-7
PubChem Compound ID
219018
PubChem Substance ID
9374238, 14848737, 30422397, 58107385, 78480710, 103837141, 113468404, 129141601, 134338775, 134338978, 135134501, 135650542, 144238903, 198941706, 226973436
Target and Pathway
Target(s) Melatonin receptor Target Info Agonist [536144]
KEGG Pathway Neuroactive ligand-receptor interaction
Circadian entrainment
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 529024Melatonin and its receptors: a new class of sleep-promoting agents. J Clin Sleep Med. 2007 Aug 15;3(5 Suppl):S17-23.
Ref 538829(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1351).
Ref 536144Melatonin and sleep in aging population. Exp Gerontol. 2005 Dec;40(12):911-25. Epub 2005 Sep 23.

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