Drug General Information
Drug ID
D0K5HI
Former ID
DCL000241
Drug Name
Talnetant
Synonyms
Talnetant [INN]; SB 223412; SB-223412; N-((S)-alpha-Ethylbenzyl)-3-hydroxy-2-phenylcinchoninamide;N-(alpha-Ethylbenzyl)-3-hydroxy-2-phenylquinoline-4-carboxamide; 3-hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide
Drug Type
Small molecular drug
Indication Schizophrenia; Schizoaffective disorders [ICD9: 295, 295.70; ICD10:F20, F25] Discontinued in Phase 2 [536224], [539353]
Irritable bowel syndrome [ICD9: 564.1, 787.91; ICD10:A09, K58, K59.1] Discontinued in Phase 2 [536224], [539353]
Company
GlaxoSmithKline
Structure
Download
2D MOL

3D MOL

Formula
C25H22N2O2
InChI
InChI=1S/C25H22N2O2/c1-2-20(17-11-5-3-6-12-17)27-25(29)22-19-15-9-10-16-21(19)26-23(24(22)28)18-13-7-4-8-14-18/h3-16,20,28H,2H2,1H3,(H,27,29)/t20-/m0/s1
InChIKey
BIAVGWDGIJKWRM-FQEVSTJZSA-N
CAS Number
CAS 174636-32-9
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Nigral tachykinin NK(3) receptor Target Info Antagonist [536865], [536894], [537495]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Reactome G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 536224Emerging drugs for irritable bowel syndrome. Expert Opin Emerg Drugs. 2006 May;11(2):293-313.
Ref 539353(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2132).
Ref 536865Augmentation of antipsychotic-induced neurochemical changes by the NK3 receptor antagonist talnetant (SB-223412). Neuropharmacology. 2009 Feb;56(2):342-9. Epub 2008 Sep 18.
Ref 536894The tachykinin NK3 receptor agonist senktide induces locomotor activity in male Mongolian gerbils. Eur J Pharmacol. 2008 Dec 14;600(1-3):87-92. Epub 2008 Oct 10.
Ref 537495Pharmacological characterization of senktide-induced tail whips. Neuropharmacology. 2009 Jun 21.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.