Drug General Information
Drug ID
D09BZY
Former ID
DIB013761
Drug Name
Nibentan
Synonyms
HE-11; Rac-N-[5-(Diethylamino)-1-phenylpentyl]-4-nitrobenzamide hydrochloride
Drug Type
Small molecular drug
Indication Cardiac arrhythmias [ICD9: 427; ICD10:I47-I49] Phase 1 [534342]
Structure
Download
2D MOL

3D MOL

Formula
C22H30ClN3O3
Canonical SMILES
CCN(CC)CCCCC(C1=CC=CC=C1)NC(=O)C2=CC=C(C=C2)[N+](=O)[O-<br />].Cl
InChI
1S/C22H29N3O3.ClH/c1-3-24(4-2)17-9-8-12-21(18-10-6-5-7-11-18)23-22(26)19-13-15-20(16-14-19)25(27)28;/h5-7,10-11,13-16,21H,3-4,8-9,12,17H2,1-2H3,(H,23,26);1H
InChIKey
CHCBAYRWJULIDW-UHFFFAOYSA-N
CAS Number
CAS 157832-55-8
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Potassium channel Target Info Blocker [527507], [531635]
References
Ref 534342Electrophysiologic effects of nibentan (HE-11) on canine cardiac tissue. J Pharmacol Exp Ther. 1997 Mar;280(3):1137-46.
Ref 527507Nibentan -- a drug for pharmacological cardioversion of persistent atrial fibrillation. Kardiologiia. 2005;45(3):19-23.
Ref 531635Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36.

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