Drug Information

Drug General Information
Drug ID
D0O9XN
Former ID
DIB006258
Drug Name
APD-597
Synonyms
JNJ-38431055
Drug Type
Small molecular drug
Indication Type 2 diabetes [ICD9: 250; ICD10:E11] Phase 1 [522679], [541062]
Company
Arena Pharmaceuticals Inc
Structure
Download
2D MOL

3D MOL
Formula
C21H29N5O6S
InChI
InChI=1S/C21H29N5O6S/c1-13(2)31-21(27)26-10-8-15(9-11-26)32-20-18(30-4)19(22-12-23-20)25-16-6-7-17(24-14(16)3)33(5,28)29/h6-7,12-13,15H,8-11H2,1-5H3,(H,22,23,25)
InChIKey
WPDCHTSXOPUOII-UHFFFAOYSA-N
PubChem Compound ID
11691484
PubChem Substance ID
16795836, 23786002, 42858402, 79931238, 136921704, 136968621, 139225975, 163642851, 172821456, 178102353, 198956289, 224032604, 226716782, 246816065
Target and Pathway
Target(s) Glucose-dependent insulinotropic receptor Target Info Agonist [531766]
KEGG Pathway cAMP signaling pathway
Insulin secretion
WikiPathways Incretin Synthesis, Secretion, and Inactivation
References
Ref 522679ClinicalTrials.gov (NCT00910923) A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of JNJ-38431055 in Healthy Male Volunteers. U.S. National Institutes of Health.
Ref 541062(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5727).
Ref 531766Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profile. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1750-5.

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