Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D07JBE
|
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| Former ID |
DIB015306
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| Drug Name |
CG-200745
|
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| Synonyms |
CG-0006; CG-005; HDAC inhibitors (cancer, oral/intravenous), CrystalGenomics; Histone deacetylase inhibitors (cancer, oral/intravenous), CrystalGenomics
|
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| Indication | Cancer [ICD9: 140-229; ICD10:C00-C96] | Phase 1 | [1] | ||
| Company |
CrystalGenomics Inc
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| Structure |
|
Download2D MOL |
|||
| Canonical SMILES |
c1ccc2c(c1)cccc2OC/C(=C\CCCCC(=O)NO)/C(O)NCCCN(C)C
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| Target and Pathway | |||||
| Target(s) | Histone deacetylase | Target Info | Inhibitor | [2] | |
| References | |||||
| REF 1 | ClinicalTrials.gov (NCT01226407) Examine Maximum Tolerated Dose and Pharmacokinetic and Pharmacodynamic Profile. U.S. National Institutes of Health. | ||||
| REF 2 | Epigenetic modulation with HDAC inhibitor CG200745 induces anti-proliferation in non-small cell lung cancer cells. PLoS One. 2015 Mar 17;10(3):e0119379. | ||||
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